Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL in [Li, Zhiwei; Xu, Le; Zhu, Liangyu; Zhao, Yanfang; Liu, Yajing; Hou, Yunlei] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Hu, Tao; Yin, Bixi; Hou, Yunlei] Yangtze River Pharmaceut Grp Pharmaceut Co Ltd, 1 South Yangtze River Rd, Taizhou 225321, Jiangsu, Peoples R China published Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors in 2020.0, Cited 21.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.
A series of novel pteridinone derivatives possessing a hydrazone moiety were designed, synthesized and evaluated for their biological activity. Most of the synthesized compounds demonstrated moderate to excellent activity against A549, HCT116 and PC-3 cancer cell lines. In particular, compound L-19 exhibited the most potent antiproliferative effects on three cell lines with IC50 values of 3.23 mu M, 4.36 mu M and 8.20 mu M, respectively. In kinase assays, the compound L-19 also showed potent inhibition activity toward PLK1 with % inhibition values of 75.1. Further mechanism studies revealed that compound L-19 significantly inhibited proliferation of HCT-116 cell lines, induced a great decrease in mitochondrial membrane potential resulting in apoptosis of cancer cells, inhibited the migration of tumor cells, and arrested G1 phase of HCT116 cells.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL or concate me.. Quality Control of 3-Hydroxybenzaldehyde
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles