Ishii, Hisashi’s team published research in Tetrahedron Letters in | CAS: 20538-12-9

Tetrahedron Letters published new progress about 20538-12-9. 20538-12-9 belongs to indole-building-block, auxiliary class Indole,Ester,Ether, name is Ethyl 7-methoxy-1H-indole-2-carboxylate, and the molecular formula is C12H13NO3, Computed Properties of 20538-12-9.

Ishii, Hisashi published the artcileSubstitution and migration of methoxyl group in the Fischer indolization of ethyl pyruvate 2-methoxyphenylhydrazone, Computed Properties of 20538-12-9, the publication is Tetrahedron Letters (1970), 1181-4, database is CAplus.

The indolization of 2-MeOC6H4NHN:CMeCO2Et (I) with 3M HCl-EtOH gave Et 6-chloroindole-2-carboxylate, Et 7-methoxyindole-2-carboxylate (II), and Et 6-ethoxyindole-2-carboxylate. The treatment of I with BF3 in AcOH or AcOEt gave IIk, Et indole-2-carboxylate (III), and Et 5-methoxyindole-2-carboxylate (IV). The treatment of I with H2SO4, in AcOH gave II, III, and IV. A mechanism involving substitution and migration of the MeO group is discussed.

Tetrahedron Letters published new progress about 20538-12-9. 20538-12-9 belongs to indole-building-block, auxiliary class Indole,Ester,Ether, name is Ethyl 7-methoxy-1H-indole-2-carboxylate, and the molecular formula is C12H13NO3, Computed Properties of 20538-12-9.

Referemce:
https://www.nature.com/articles/s41429-020-0333-2,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles