The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists was written by Jablonowski, Jill A.;Grice, Cheryl A.;Chai, Wenying;Dvorak, Curt A.;Venable, Jennifer D.;Kwok, Annette K.;Ly, Kiev S.;Wei, Jianmei;Baker, Sherry M.;Desai, Pragyna J.;Jiang, Wen;Wilson, Sandy J.;Thurmond, Robin L.;Karlsson, Lars;Edwards, James P.;Lovenberg, Timothy W.;Carruthers, Nicholas I.. And the article was included in Journal of Medicinal Chemistry in 2003.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid This article mentions the following:
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified a potential lead compound Investigation of the structure-activity relationship (SAR) resulted in the discovery of novel compounds, which are the first potent and selective histamine H4 receptor antagonists to be described. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid).
4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles