Jia, Xue-Gong et al. published their research in Chemical Science in 2018 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate

Dual nickel and Lewis acid catalysis for cross-electrophile coupling: the allylation of aryl halides with allylic alcohols was written by Jia, Xue-Gong;Guo, Peng;Duan, Jicheng;Shu, Xing-Zhong. And the article was included in Chemical Science in 2018.Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate This article mentions the following:

A general and practical strategy to address the reaction between reactive and unreactive electrophiles by a combination of nickel and Lewis acid catalysis is reported. This strategy is used for the coupling of aryl bromides R1Br (R1 = 4-MeO2CC6H4, benzofuran-5-yl, indol-4-yl, etc.) with allylic alcs. R2CH:CHCR3R4OH (R2 = H, Me, Ph, etc.; R3 = R4 = H, Me; R3 = Me, Et, Ph, R4 = H) to form linear allylarenes R1CR3R4CH:CHR2. The reaction tolerates a wide range of functional groups (e.g. silanes, boronates, anilines, esters, alcs., and various heterocycles) and works with various allylic alcs. Complementary to most current routes for the C3 allylation of an unprotected indole, this method provides access to C2 and C4-C7 allylated indoles. Preliminary mechanistic experiments revealed that the reaction might start with an aryl nickel intermediate, which then reacts with Lewis acid activated allylic alcs. in the presence of Mn. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate).

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of Methyl 5-bromo-1H-indole-2-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles