Product class 13: indole and its derivatives was written by Joule, J. A.. And the article was included in Science of Synthesis in 2001.Reference of 16732-64-2 This article mentions the following:
A review of preparation of indoles and its derivatives Covered reactions include cyclization, ring transformation, aromatization and substituent modifications. Subclasses covered include 1H-indol-1-ols, 1,3-dihydro-2H-indol-2-ones, and 1,2-dihydro-3H-indol-3-ones. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Reference of 16732-64-2).
4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Reference of 16732-64-2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles