On February 16, 2018, Kong, Xiang-Fei; Zhan, Feng; He, Guo-Xue; Pan, Cheng-Xue; Gu, Chen-Xi; Lu, Ke; Mo, Dong-Liang; Su, Gui-Fa published an article.HPLC of Formula: 883526-76-9 The title of the article was Gold-Catalyzed Selective 6-exo-dig and 7-endo-dig Cyclizations of Alkyne-Tethered Indoles To Prepare Rutaecarpine Derivatives. And the article contained the following:
An efficient method to synthesize rutaecarpine derivatives I [R1 = H, OMe-3, Me-3, Cl-3, Br-3, I-3, F-2, Cl-4; R2 = Me, CH2Ph, H; R3 = Me-10, Br-10, Cl-11; R4 = H, Me, SiMe3] and II [R1 = H, OMe, Cl, Br, I; R3 = H, Cl; R4 = H, Me, Ph, SiMe3] via the gold-catalyzed selective cyclization of alkyne-tethered indoles III under mild conditions is described. The alkyne-tethered indole can undergo 6-exo-dig cyclization by oxidation and sequential gold catalysis, while it goes through 7-endo-dig cyclization by gold catalysis and sequential oxidation Substrate scope studies reveal that the selectivity of cyclization was controlled by the substrates with sp3 and sp2 hybridization of carbon at the 2 position in quinazolinone. Furthermore, the rutaecarpine scaffold was prepared in 67% yield at gram scale easily in four steps from isatoic anhydride. The experimental process involved the reaction of 1,5-Dimethyl-1H-indole-2-carbaldehyde(cas: 883526-76-9).HPLC of Formula: 883526-76-9
The Article related to rutaecarpine alkaloid derivative scaffold preparation, quinazolinone alkyne tethered indoles gold catalyzed selective cyclization, exo dig cyclization gold catalysis quinazolinone alkyne tethered indoles, endo dig cyclization gold catalysis quinazolinone alkyne tethered indoles and other aspects.HPLC of Formula: 883526-76-9
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles