Recently I am researching about PROCESS WINDOWS; CHEMISTRY; REACTORS; LIQUID; SAFE, Saw an article supported by the Spanish MINECO [RTI2018-095588-B-I00]; European Regional Development Fund/European Social Fund, Investing in your future; FUSP-CEU [PC17/17]; Fundacion San Pablo-CEU. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Garcia-Lacuna, J; Dominguez, G; Blanco-Urgoiti, J; Perez-Castells, J. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Quality Control of 3-Hydroxybenzaldehyde
A new synthesis of treprostinil is described using a plug flow reactor in two of the key steps. First, a Claisen rearrangement reaction is described in scaled flow at multigram amounts. Yields and selectivity of this step are sharply improved compared to those from previous syntheses. Second, the key Pauson-Khand reaction in flow is described under catalytic conditions with 5 mol% of cobalt carbonyl and only 3 equiv. of CO. Scaling up of this reaction safely ensures a good yield of an advanced intermediate which is transformed into treprostinil in three steps. Other improvements are the introduction of the carboxymethyl chain into the phenol from the beginning to reduce the protection-deprotection steps. The synthesis is completed in 14% global yield after 12 linear steps from (S)-epichlorhydrin.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Garcia-Lacuna, J; Dominguez, G; Blanco-Urgoiti, J; Perez-Castells, J or concate me.. Quality Control of 3-Hydroxybenzaldehyde
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles