COA of Formula: C7H8O2. I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities published in 2021.0, Reprint Addresses Teinkela, JEM (corresponding author), ULB, Fac Pharm, Unite Microbiol Chim Bioorgan & Macromol, Dept R3D, Brussels, Belgium.; Noundou, XS (corresponding author), Rhodes Univ, Fac Sci, Dept Chem, Nanomat & Med Organ Chem Lab, Grahamstown, South Africa.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol.
Terminaliamide (1), a new ceramide was isolated from the roots of Terminalia mantaly H. Perrier (Combretaceae) along with 4 known compounds (2-5). The structures of the compounds were elucidated using 1D and 2D NMR spectroscopy analysis and mass spectrometry. Compound 1 exhibited moderated antibacterial activity towards Staphylococcus aureus with MIC value of 62.5 mu g/mL. The crude MeOH extract (TMr) highly reduced Plasmodium falciparum growth with an IC50 value of 10.11 mu g/mL, while hexane fraction (F1) highly reduced Trypanosoma brucei brucei growth with an IC50 value of 5.60 mu g/mL. All tested samples presented little or no in vitro cytotoxicity on HeLa cell line. The present work confirms that T. mantaly is medicinally important and may be used effectively as an antimicrobial, an antiplasmodial and an antitrypanosomial with promising therapeutic index.
COA of Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Teinkela, JEM; Noundou, XS; Fannang, S; Song, AM; Nguedia, JCA; Hoppe, HC; Krause, RWM or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles