On September 2, 2016, Lian, Xiao-Lei; Meng, Jing; Han, Zhi-Yong published an article.COA of Formula: C8H8ClN The title of the article was Ru(II)/Organo Relay Catalytic Three-Component Reaction of 3-Diazooxindoles, Amines, and Nitroalkene: Formal Synthesis of (-)-Psychotrimine. And the article contained the following:
A highly enantioselective carbenoid-associated N-H functionalization/Michael addition cascade reaction is developed by virtue of Ru(II)/chiral organo bifunctional catalyst relay catalysis. In this way, a variety of optically pure 3-amino-3-alkyloxindoles, I (R1 = H, 5-MeO, 5-Me, 5-Cl, 5-F, 6-Br, 7-Br, R2R3N = indolin-1-yl, 6-chloroindolin-1-yl, N-benzylphenylamino, etc.) can be easily achieved. Moreover, on the basis of this metal/organo relay catalytic three-component protocol, key intermediate II, for the formal synthesis of (-)-psychotrimine, could be obtained in six steps with 25% overall yield. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN
The Article related to relay catalytic three component reaction diazooxindole amine nitroalkene ruthenium, enantioselective synthesis psychotrimine, stereoselective michael addition cascade ruthenium chiral organo bifunctional catalyst and other aspects.COA of Formula: C8H8ClN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles