Discovery of Pyrrolo[2,3-b]pyridine (1,7-Dideazapurine) Nucleoside Analogues as Anti-Trypanosoma cruzi Agents was written by Lin, Cai;Hulpia, Fabian;da Silva, Cristiane Franca;Batista, Denise da Gama Jaen;Van Hecke, Kristof;Maes, Louis;Caljon, Guy;Soeiro, Maria de Nazare C.;Van Calenbergh, Serge. And the article was included in Journal of Medicinal Chemistry in 2019.Safety of 3-Bromo-4-chloro-7-azaindole This article mentions the following:
Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for cardiac-related mortality in Latin-America triggered by an infective agent. Incapable of synthesizing purines de novo, this parasite depends on acquisition and processing of host-derived purines, making purine (nucleoside) analogs a potential source of antitrypanosomal agents. In this respect, hitherto 7-deazaadenosine (tubercidin) analogs attracted most attention. Here, we investigated analogs with an addnl. nitrogen (N1) removed. Structure-activity relationship investigation showed that C7 modification afforded analogs with potent antitrypanosomal activity. Halogens and small, linear carbon-based substituents were preferred. Compound 11 proved most potent in vitro, showed full suppression of parasitemia in a mouse model of acute infection, and elicited 100% animal survival after oral dosing at 25 mg/kg b.i.d. for 5 and 15 days. Cyclophosphamide-induced immunosuppression led to recrudescence. Washout experiments demonstrated a lack of complete clearance of infected cell cultures, potentially explaining the in vivo results. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-chloro-7-azaindole (cas: 1000340-39-5Safety of 3-Bromo-4-chloro-7-azaindole).
3-Bromo-4-chloro-7-azaindole (cas: 1000340-39-5) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Safety of 3-Bromo-4-chloro-7-azaindole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles