Enantioselective Propargylation of Oxonium Ylide with α-Propargylic-3-Indolymethanol: Access to Chiral Propargylic Indoles was written by Liu, Xiangrong;Tian, Xue;Huang, Jiawu;Qian, Yu;Xu, Xinfang;Kang, Zhenghui;Hu, Wenhao. And the article was included in Organic Letters in 2022.Application of 827-01-0 This article mentions the following:
An enantioselective three-component reaction of diazoindolinones I (R1 = 6-OMe, 5-Me, 5-Cl, etc.; R2 = Me, Bn) with alc. R3OH (R3 = Me, benzyl, naphthalen-2-ylmethyl, etc.) and α-propargylic-3-indolymethanols II (R4 = TMS, TBS, TIPS, Ph, t-Bu; R5 = 7-Me, 5-OMe, 5-Cl, 6-OMe, 2-Ph) under cocatalysis of Rh(II) and chiral phosphoric acid (CPA) has been reported. It proceeds through the regio- and enantiospecific addition of the in situ formed oxonium ylide to the α-propargylic indole iminium ion that is generated from 3-indolyl propargylic alc. II with CPA. This work features an asym. counteranion-directed propargylation of oxonium ylide, and provides an efficient access to chiral propargylic indole derivatives syn-III and IV with high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Application of 827-01-0).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 827-01-0
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles