Design, synthesis and antitumor activity of novel indolin-2-one derivatives containing 4-thiazolidinone moiety was written by Liu, Zijian;Hou, Yunlei;Zhang, Guogang;Xu, Ning;Mi, Bin;Gong, Ping;Zhao, Yanfang. And the article was included in Chemical Research in Chinese Universities in 2015.Quality Control of 5,6-Difluoroindolin-2-one This article mentions the following:
A series of novel indolin-2-one derivatives containing 4-thiazolidinone moiety(7a-7r) were synthesized and evaluated for their in vitro antitumor activities against MDA-MB-231(human breast cancer), H460(human lung cancer) and HT-29(human colon cancer) cell lines by standard 3-(4,5-dimethylthiazae-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. Representative compounds(7d, 7k, 7m, 7p) with higher cytotoxicity were further examined against one normal cell line(WI-38, human fetal lung fibroblasts). The preliminary investigation shows that most of the compounds display moderate to excellent potency and high selectivity against different human cancer cell lines. In particular, the most potent compound 7m shows promising cytotoxicity against MDA-MB-231, H460 and HT-29 cell lines with IC50 values of 0.78, 0.056 and 0.018 渭mol/L, resp. The potency is much higher than that of Sunitinib(IC50=3.46 渭mol/L against MDA-MB-231, IC50=2.59 渭mol/L against H460, IC50=1.50 渭mol/L against HT-29) by 4.4, 46.3 and 83.3 fold. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Quality Control of 5,6-Difluoroindolin-2-one).
5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 5,6-Difluoroindolin-2-one
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles