《Highly enantioselective electrosynthesis of C2-quaternary indolin-3-ones》 was written by Lu, Fo-Yun; Chen, Yu-Jue; Chen, Yuan; Ding, Xuan; Guan, Zhi; He, Yan-Hong. COA of Formula: C8H6FN And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:
A highly enantioselective and direct synthesis of C2-quaternary indolin-3-ones from 2-arylindoles by combining electrochem. and organocatalysis is described. Excellent enantioselectivities (up to 99% ee) and diastereoselectivities (>20 : 1) can be obtained through anodic oxidation in combination with asym. proline-catalyzed alkylation in an undivided cell under constant-current conditions. Thus, e.g., 2-phenylindole + cyclohexanone → I (67%, > 20:1 d.r., 98% ee) in presence of L-proline as chiral organic catalyst using DMF as solvent, TFE as cosolvent, TEMPO as mediator, benzoic acid as additive and tetrabutylammonium perchlorate as electrolyte in undivided cell with Pt anode and cathode. In the experiment, the researchers used 5-Fluoro-1H-indole(cas: 399-52-0COA of Formula: C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.COA of Formula: C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles