Recently I am researching about AGENTS; 4-THIAZOLIDINONES; ANALOGS; THIAZOLIDIN-4-ONE; CYTOTOXICITY; MICROTUBULES; POTENT; QSAR, Saw an article supported by the Department of Pharmaceuticals (DoP), Ministry of Chemicals & Fertilizers, Govt. of India, New Delhi,. Product Details of 120-14-9. Published in ELSEVIER in AMSTERDAM ,Authors: Sigalapalli, DK; Pooladanda, V; Kadagathur, M; Guggilapu, SD; Uppu, JL; Godugu, C; Bathini, NB; Tangellamudi, ND. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde
Here-in, we present molecular design, chemical synthesis and evaluation of novel chromenyl-based 2-iminothiazolidin-4-one derivatives as tubulin polymerization inhibitors. The newly synthesized compounds were evaluated for their in vitro cytotoxicities against A549 (lung cancer), MDA-MB-231 and BT-471 (breast cancer), HepG2 (liver cancer) and HCT-116 (colon cancer) cell lines by MTT assay. Among the synthesized compounds, compound 12b showed excellent anticancer activity on MDA-MB-231 cell line with IC50 value of 0.95 +/- 1.88 mu M and was verified to be safe in normal human bronchial epithelial cells (Beas-2B). Apoptosis induced by the lead 12b was observed using morphological observations, AO/EB and DAPI staining procedures. Further, dose-dependent increase in the depolarization of mitochondrial membrane was also observed through JC-1 staining. Annexin V-FITC/PI assay confirmed that 12b induced early apoptosis. Additionally, cell cycle analysis indicated that the MDA-MB-231 cells were arrested at sub-G2/M phase and also inhibited tubulin polymerization with IC50 value of 3.54 +/- 0.2 mM. Molecular docking simulations were employed to identify the important binding modes responsible for the tubulin inhibitory activity, thus supporting their effective anticancer potential. (c) 2020 Published by Elsevier B.V.
Product Details of 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Sigalapalli, DK; Pooladanda, V; Kadagathur, M; Guggilapu, SD; Uppu, JL; Godugu, C; Bathini, NB; Tangellamudi, ND or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles