Synthesis of novel 4,5-dihydropyrrolo[1,2-a]quinoxalines, spiro[dihydroindolone-pyrrolo[1,2-a]quinoxaline] derivatives and their antituberculosis and anticancer activity was written by Makane, Vitthal B.;Vamshi Krishna, Eruva;Karale, Uattam B.;Babar, Dattatraya A.;Kalari, Saradhi;Rekha, Estharla M.;Shukla, Manjulika;Kaul, Grace;Sriram, Dharmarajan;Chopra, Sidharth;Misra, Sunil;Rode, Haridas B.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2020.Synthetic Route of C10H9NO2 The following contents are mentioned in the article:
A facile strategy was developed for the synthesis of biol. important 4,5-dihydropyrrolo[1,2-a]quinoxalines I (R = H, F; R1 = 4-Me, 2-Br, 4-Cl; R2 = H, Cl, Me) and spiro derivatives II (R3 = H, Me, Bn; R4 = H, Me; R5 = H, Me, Cl, F, I, OCF3; R6 = H, Me) by treating 2-(1H-pyrrol-1-yl)anilines 4-R-2-(1H-pyrrol-1-yl)C6H3NH2 such as with imidazo[1,2-a]pyridine-3-carbaldehydes III or isatins IV, using amidosulfonic acid (NH3SO3) as a solid catalyst in water at room temperature The protocol has been extended to electrophile ninhydrin. The catalyst could be recycled for six times without the loss of activity. The compounds I, II, V were evaluated for their antituberculosis, antibacterial, and anticancer activities. It is worth noting that compounds I (R = H, R1 = 2-Br, R2 = Cl, Me) demonstrated a min. inhibitory concentration value of 6.25μM against Mycobacterium tuberculosis H37Rv, whereas compounds I (R = H, R1 = 2-Br, R2 = Cl; R = F, R1 = 2-Br, R2 = H), II (R = H, R3 = H, R4 = H, R5 = I, OCF3, R6 = H; R = H, R3 = Bn, R4 = H, R5 = H, R6 = H) showed a remarkable inhibition of A549, DU145, HeLa, HepG2, MCF-7, and B16-F10 cell lines, resp. Staphylococcus aureus was inhibited by compounds II (R = H, R3 = H, R4 = H, R5 = Cl, I, OCF3, R6 = H; R = H, F, R3 = H, R4 = Me, R5 = H, R6 = Me) at 32μg/mL. This study involved multiple reactions and reactants, such as 4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6Synthetic Route of C10H9NO2).
4,7-Dimethylindoline-2,3-dione (cas: 15540-90-6) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Synthetic Route of C10H9NO2
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles