Visible-Light-Irradiated Cascade Reaction of Indole-Tethered Alkenes to Access Tetracyclic Tetrahydro-γ-carbolines was written by Mei, Haibo;Liu, Aiyao;He, Jingrui;Yu, Yingjie;Han, Jianlin. And the article was included in Organic Letters in 2022.Quality Control of 5-Chloroindole-3-carboxaldehyde This article mentions the following:
A series of indole-derived alkenes I (R = H, Cl, Br; R1 = Me, OMe, F, etc.; R2 = H, Me, F, etc.; R3 = R4 = H, Me; Ar = Ph, 4-methylphenyl, 4-bromophenyl, 4-methyoxphenyl) have been designed and applied in a photocatalytic cascade reaction with bromodifluoroacetate esters BrCF2C(O)OR5 (R5 = Me, Bn, cyclopentyl, etc.), affording an unknown type of tetracyclic tetrahydro-γ-carboline derivative II in up to 90% yields. Mechanistic studies suggest that the reaction proceeds with tetrahydro-γ-carboline III (Ar = 4-methylphenyl, R5 = Et;) as a key intermediate. The reaction tolerates a diverse pool of substrates, which provides an efficient method for the construction of tetracyclic tetrahydro-γ-carboline II compounds In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Quality Control of 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 5-Chloroindole-3-carboxaldehyde
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles