《Regiospecificity in Ligand-Free Pd-Catalyzed C-H Arylation of Indoles: LiHMDS as Base and Transient Directing Group》 was written by Mohr, Yorck; Renom-Carrasco, Marc; Demarcy, Clement; Quadrelli, Elsje Alessandra; Camp, Clement; Wisser, Florian M.; Clot, Eric; Thieuleux, Chloe; Canivet, Jerome. COA of Formula: C8H6FN And the article was included in ACS Catalysis in 2020. The article conveys some information:
A highly efficient catalyst-base pair for the C-H arylation of free (NH)-indoles in the C-3 position was reported. Ligand-free palladium acetate coupled with lithium hexamethyldisilazide (LiHMDS) catalyzed the regiospecific, i.e. 100% regioselective, C-3 arylation of indoles with high turnover numbers This catalytic system was successfully applied to a wide range of substrates including various functional aryl halides and indolic cores. The unique role of LiHMDS as both a base and unexpected transient directing group was revealed exptl. and elucidated computationally, in line with a Heck-type insertion-elimination mechanism. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0COA of Formula: C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.COA of Formula: C8H6FN
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles