Application In Synthesis of 4′-Hydroxyacetophenone. Recently I am researching about DERIVATIVES; CHALCONE; DESIGN; AMONAFIDE; DOCKING; INHIBITORS; APOPTOSIS; BINDING; BCL-2, Saw an article supported by the Department of Science and Technology (DST), New Delhi, India, under INSPIRE programmeDepartment of Science & Technology (India)Department of Science & Technology (DOST), Philippines [Shalini IF160180]; National Research Foundation South AfricaNational Research Foundation – South Africa [121276]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Shalini; Pankaj; Saha, ST; Kaur, M; Oluwakemi, E; Awolade, P; Singh, P; Kumar, V. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone
A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, i.e. MCF-7 (ER+), and triple-negative, i.e. MDA-MB-231 (ER-), cell lines. The structure-activity-relationship (SAR) was deduced based on the influence of linker length, substituents on the phenyl ring and the generated functionalities, on anti-proliferative activities. Docking simulations further delineate the type of interactions of the designed molecules with the selected targets. This report discloses the scope of triazole tethered naphthalimide-chalcone/pyrazoline conjugates as anti breast cancer agents.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles