Quality Control of 4′-Hydroxyacetophenone. Yuan, ZB; Zeng, YY; Feng, ZW; Guan, Z; Lin, AJ; Yao, HQ in [Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan] China Pharmaceut Univ, State Key Lab Nat Med SKLNM, Sch Pharm, Nanjing 210009, Peoples R China; [Yuan, Zhenbo; Zeng, Yuye; Feng, Ziwen; Guan, Zhe; Lin, Aijun; Yao, Hequan] China Pharmaceut Univ, Dept Med Chem, Sch Pharm, Nanjing 210009, Peoples R China published Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes in 2020.0, Cited 52.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
Transition-metal-catalyzed tandem Heck/carbonylation reaction has emerged as a powerful tool for the synthesis of structurally diverse carbonyl molecules, as well as natural products and pharmaceuticals. However, the asymmetric version was rarely reported, and remains a challenging topic. Herein, we describe a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes. Alcohols, phenols and amines are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asymmetric tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes. Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes with alcohols, phenols and amines.
About 4′-Hydroxyacetophenone, If you have any questions, you can contact Yuan, ZB; Zeng, YY; Feng, ZW; Guan, Z; Lin, AJ; Yao, HQ or concate me.. Quality Control of 4′-Hydroxyacetophenone
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles