Name: 3-Hydroxybenzaldehyde. In 2019.0 BIOORG CHEM published article about HELICOBACTER-PYLORI UREASE; BIOLOGICAL EVALUATION; PROTEUS-MIRABILIS; BACTERIAL UREASE; DERIVATIVES; VISUALIZATION; INFECTIONS; CHEMISTRY; DESIGN in [Isaac, Ibanga Okon; Hameed, Abdul; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan; [Al-Rashida, Mariya] A Chartered Univ, Dept Chem, Forman Christian Coll, Ferozepur Rd, Lahore 54600, Pakistan; [Rahman, Shafiq Ur; Iqbal, Jamshed] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad 22060, Pakistan; [Alharthy, Rima D.] King Abdulaziz Univ, Dept Chem Sci & Arts Coll, Rabigh Campus, Jeddah, Saudi Arabia; [Asari, Asnuzilawati] Univ Malaysia Terengganu, Sch Fundamental Sci, Kuala Nerus 21030, Terengganu, Malaysia; [Khan, Khalid Mohammed] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 31441, Dammam, Saudi Arabia in 2019.0, Cited 37.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.
Urease is a bacterial enzyme that is responsible for virulence of various pathogenic bacteria such as Staphylococcus aureus, Proteus mirabilis, Klebsiella pneumoniae, Ureaplasma urealyticum, Helicobacter pylori and Mycobacterium tuberculosis. Increased urease activity aids in survival and colonization of pathogenic bacteria causing several disorders especially gastric ulceration. Hence, urease inhibitors are used for treatment of such diseases. In search of new molecules with better urease inhibitory activity, herein we report a series of acridine derived (thio) semicarbazones (4a-4e, 6a-6l) that were found to be active against urease enzyme. Molecular docking studies were carried out to better comprehend the preferential mode of binding of these compounds against urease enzyme. Docking against urease from pathogenic bacterium S. pasteurii was also carried out with favorable results. In silico ADME evaluation was done to determine drug likeness of synthesized compounds.
Welcome to talk about 100-83-4, If you have any questions, you can contact Isaac, IO; Al-Rashida, M; Rahman, SU; Alharthy, RD; Asari, A; Hameed, A; Khan, KM; Iqbal, J or send Email.. Name: 3-Hydroxybenzaldehyde
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles