An article Discovery of 4H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models WOS:000503114200013 published article about RETINAL EXPLANT CULTURES; PHOSPHORYLATION in [Zhao, Lanying; Li, Yueshan; Qiao, Zeen; Miao, Zhuang; Yang, Jiao; Huang, Luyi; Yang, Shengyong] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China; [Zhao, Lanying; Li, Yueshan; Qiao, Zeen; Miao, Zhuang; Yang, Jiao; Huang, Luyi; Yang, Shengyong] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China; [Wang, Yujiao; Chen, Danian] Sichuan Univ, West China Hosp, Dept Ophthalmol, Research Lab Ophthalmol & Vis Sci, Chengdu 610041, Sichuan, Peoples R China; [Tian, Chenyu; Li, Linli] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Sichuan, Peoples R China in 2019.0, Cited 27.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Application In Synthesis of m-Methoxyphenol
Diabetic retinopathy (DR) is a major cause of blindness, and there is a lack of effective treatment at present. Rho-associated coiled-coil containing serine/threonine protein kinases (ROCKs) have recently been suggested as potential targets for the DR treatment. We herein report the discovery of 4H-chromen-4-one derivatives as a new class of ROCK inhibitors. Structure-activity relationship analyses led to the identification of the most active compound, 4-(dimethylamino)-N-(3-{2-[(4-oxo-4H-chromen-7-yl)oxy]acetamido}phenyl) (12j). This compound showed excellent kinase selectivity for ROCK I and ROCK II against 387 other kinases. In retinal explants, compound 12j protected retinal neurons from high glucose-induced oxidative stress and apoptosis-mediated cell death. Furthermore, 12j administration suppressed the improper proliferation of Muller cells and promoted the regression of vascular vessels in retinal explants cultured in a high glucose microenvironment. Collectively, our data suggest that 12j could be a potential lead compound for the treatment of DR, hence deserving further in-depth studies.
Application In Synthesis of m-Methoxyphenol. Welcome to talk about 150-19-6, If you have any questions, you can contact Zhao, LY; Li, YS; Wang, YJ; Qiao, Z; Miao, Z; Yang, J; Huang, LY; Tian, CY; Li, LL; Chen, DN; Yang, SY or send Email.
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles