With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120-72-9,1H-Indole,as a common compound, the synthetic route is as follows.
To a solution of indole (10.021 g, 85 mmol) in diethyl ether (150 mL) was added oxalyl chloride (11.0 mL, 16.3 g, 0.13 mol) dropwise over 10 minutes and the yellow suspension was allowed to stir for a further 30 minutes at room temperature. Saturated aqueous sodium bicarbonate (20 mL) was then added with caution and the biphasic mixture was stirred for 16 hours. The product was then collected using vacuum filtration, washed with diethyl ether and dried overnight at 40 C to give a yellow solid (14.167 g, 88%): m.p. 193-196 C; (Lit. 210 C decomp.)47; numax/cm-1(KBr) 3549, 3195, 1719, 1611, 1268; deltaH(300 MHz, DMSO-d6) 7.26 [1H, ddd,J9.1, 7.1, 1.7, C(5)-H], 7.29 [1H, ddd,J9.3, 7.1, 1.9, C(6)-H], 7.52-7.58 [1H, m, C(7)-H], 8.14-8.20 [1H, m, C(4)-H], 8.42 [1H, d,J3.3, C(2)-H], 12.36 (1H, bs, N-H); m/z (ESI+) = 190.3 [(M+H)+100%]., 120-72-9
The synthetic route of 120-72-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Winfield, Hannah J.; Cahill, Michael M.; O’Shea, Kevin D.; Pierce, Larry T.; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Marchand, Pascal; McCarthy, Florence O.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4209 – 4224;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles