348-36-7, Ethyl 5-fluoro-1H-indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Ethyl 5-fluoro-1H-indole-2-carboxylate (2 g, 9.7 mmol) and 1H-pyrrole-2,5-dione (1.40 g, 14.4 mmol)were added to dry 1,2-dichloroethane (50 mL), and 46.5% BF3-Et2O (3.54 g, 11.6 mmol) was added toreaction mixture at 20 C. After the reaction mixture was stirred at 90 C, until the starting materialdisappeared in thin layer chromatography (TLC), the reaction mixture was distilled in vacuo, anddichloromethane (50 mL) was added to the mixture. The organic extract was washed twice withsaturated aqueous NaHCO3 and NaCl (20 mL) respectively, and the organic extract was dried overNa2SO4. After solvent was removed under vacuum, the product was purified as a white solid bysilica gel column chromatography, 1.62 g, yield 55%. 1H-NMR (400 MHz, DMSO-d6): = 12.00 (s, 1H,NH-indolyl), 11.31 (s, 1H, NH), 7.49-7.45 (m, 2H, H-indolyl), 7.18 (td, J = 9.2, 2.6 Hz, 1H, H-indolyl),4.82 (dd, J = 9.6, 6.6 Hz, 1H, CH), 4.33-4.27 (m, 2H, CH2), 3.08 (dd, J = 17.7, 9.6 Hz, 1H, CH?H?), 2.70(dd, J = 17.7, 6.6 Hz, 1H, CH?H?), 1.30 (t, J = 7.1 Hz, 3H, CH3). 13C-NMR (101 MHz, CD3OD): =182.17,180.15, 162.66, 160.66, 134.24, 129.01, 126.54, 119.11, 115.66, 114.82, 104.78, 62.19, 39.68, 39.37, 14.63.HRMS (ESI): m/z [M + H]+ calculated for C15H14O4N2F: 305.09321; found: 305.09290.
348-36-7, The synthetic route of 348-36-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Wen, Hui; Liu, Yuke; Wang, Shufang; Wang, Ting; Zhang, Gang; Chen, Xiaoguang; Li, Yan; Cui, Huaqing; Lai, Fangfang; Sheng, Li; Molecules; vol. 24; 11; (2019);,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles