348640-06-2, 4-Bromo-7-azaindole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
As shown in Scheme 6,4-bromo-1H-pyrrolo[2,3-b]pyridine (1.01 g), 2-acetamidophenylboronic acid (1.63 g), Pd(PPh3)4 (0.345 mg), and 1M Na2CO3 (8 mL) were mixed in DME (20 mL) and heated at 95 C. overnight. The reaction was cooled and water (60 mL) added. Extraction with dichloromethane (3¡Á) and concentration of the combined organic extracts gave N-(2-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)acetamide (compound 1001), which was treated with concentrated hydrochloric acid (20 mL) and toluene (1 mL) and heated at 128 C. for 30 min. Evaporation of the volatiles gave a residue, to which saturated sodium bicarbonate was added. The resulting mixture was extracted with dichloromethane (3¡Á). Concentration of the organics and purification of the residue via silica gel chromatography (50 to 80% EtOAc/hexane) gave 2-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzenamine (compound 1002, 1.07 g). To compound 1002 (14 mg) in methanol (1 mL) was added 4N HCl-dioxane (0.05 mL) and benzaldehyde (16 mg). The reaction mixture was capped and heated at 90 C. for 1 h. About 75% of the methanol was removed by evaporation, followed by the addition of ethyl ether (5 mL). The resulting solid was filtered and washed with ether (2¡Á) to yield compound 5 as the hydrochloride salt (22.5 mg)., 348640-06-2
As the paragraph descriping shows that 348640-06-2 is playing an increasingly important role.
Reference£º
Patent; Vertex Pharmaceuticals Incorporated; US2010/81645; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles