399-51-9, 6-Fluoro-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 2: Isopropyl 8-fluoro-1 ,1-dimethyl-3-[4-(morpholin-4-ylmethyl)benzoyl]-1, 2,3,6- tetrahydroazepino[4,5-b]indole-5-carboxylate[00164] Step 1: In a round bottom flask with stir bar were combined acetic acid (40 ml_), formaldehyde (9.3 ml_, 114 mmol, 37% soln in water), and dimethylamine (20.0 ml_, 178 mmol, 40% soln in water). The solution was cooled to 0 0C in an ice water bath and 6-fluoroindole (15 g, 111 mmol) was added in portions over one hour. After complete addition the ice bath was removed and the reaction warmed gradually to room temperature overnight, after which time the reaction mixture was poured into ice water. The pH was adjusted to 12 with an aqueous solution of sodium hydroxide. The resulting mixture was extracted with diethyl ether (2x). The combined extracts were dried over sodium sulfate and concentrated to dryness. Further drying under vacuum provided 1-(6-fluoro-1 H-indol-3-yl)-N,N-dimethylmethanamine as a white solid, which was used without further purification in the next step. MS (ES) m/z 191.0 ([M-H] ).
399-51-9, The synthetic route of 399-51-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; WYETH; LUNDQUIST IV, Joseph Theodore; MAHANEY, Paige Erin; KIM, Younghee Callain; WO2010/36362; (2010); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles