With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6960-42-5,7-Nitro-1H-indole,as a common compound, the synthetic route is as follows.
6960-42-5, General procedure: First, a solution of a benzoheterocycle (an indole, a benzofuran or abenzo[b]thiophene) (0.3 mmol), an arylsulfonyl hydrazide (0.8 mmol),Cu(OTf)2 (0.2 mmol), HOAc (2 mL) and H2O (0.1 mL) in toluene(1 mL) was stirred at 110 C for 8 h under air. Second, the reaction mixture was quenched with water (10 mL) and extracted with EtOAc(3 ¡Á 10 mL). The combined EtOAc extracts were dried over anhydrous MgSO4 and the solvent removed under reduced pressure. The residue was purified by flash column chromatography on silica gel using PE/EtOAc as the eluent.
The synthetic route of 6960-42-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Chen, Lingjuan; Pu, Jiangxin; Liu, Ping; Dai, Bin; Journal of Chemical Research; vol. 42; 9; (2018); p. 456 – 462;,
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