COA of Formula: C7H8O. Authors Lin, HY; Chen, CY; Lin, TC; Yeh, LF; Hsieh, WC; Gao, S; Burnouf, PA; Chen, BM; Hsieh, TJ; Dashnyam, P; Kuo, YH; Tu, Z; Roffler, SR; Lin, CH in NATURE RESEARCH published article about in [Lin, Hsien-Ya; Chen, Chia-Yu; Lin, Ting-Chien; Yeh, Lun-Fu; Hsieh, Wei-Che; Gao, Shijay; Hsieh, Tung-Ju; Dashnyam, Punsaldulam; Kuo, Yen-Hsi; Tu, Zhijay; Lin, Chun-Hung] Acad Sinica, Inst Biol Chem, Taipei, Taiwan; [Lin, Hsien-Ya; Chen, Chia-Yu; Lin, Ting-Chien; Lin, Chun-Hung] Natl Taiwan Univ, Dept Chem, Taipei, Taiwan; [Burnouf, Pierre-Alain; Chen, Bing-Mae; Roffler, Steve R.] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan; [Roffler, Steve R.] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung, Taiwan; [Lin, Chun-Hung] Natl Taiwan Univ, Inst Biochem Sci, Taipei, Taiwan; [Lin, Chun-Hung] Acad Sinica, Genom Res Ctr, Taipei, Taiwan in 2021.0, Cited 38.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Irinotecan inhibits cell proliferation and thus is used for the primary treatment of colorectal cancer. Metabolism of irinotecan involves incorporation of beta -glucuronic acid to facilitate excretion. During transit of the glucuronidated product through the gastrointestinal tract, an induced upregulation of gut microbial beta -glucuronidase (GUS) activity may cause severe diarrhea and thus force many patients to stop treatment. We herein report the development of uronic isofagomine (UIFG) derivatives that act as general, potent inhibitors of bacterial GUSs, especially those of Escherichia coli and Clostridium perfringens. The best inhibitor, C6-nonyl UIFG, is 23,300-fold more selective for E. coli GUS than for human GUS (K-i=0.0045 and 105 mu M, respectively). Structural evidence indicated that the loss of coordinated water molecules, with the consequent increase in entropy, contributes to the high affinity and selectivity for bacterial GUSs. The inhibitors also effectively reduced irinotecan-induced diarrhea in mice without damaging intestinal epithelial cells. Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin and colleagues perform structure-guided modifications of the compound uronic isofagomaine in order to engineer a highly specific and potent inhibitor of gut bacterial beta -glucuronidases (GUSs). The authors present eight crystal structures and demonstrate in vivo efficacy of the optimised C6-alkyl derivative inhibitor in mice models. This study may enhance the development of inhibitors of microbial GUS for use in colorectal cancer therapy to minimize the undesired side effects of irinotecan treatment.
Welcome to talk about 100-51-6, If you have any questions, you can contact Lin, HY; Chen, CY; Lin, TC; Yeh, LF; Hsieh, WC; Gao, S; Burnouf, PA; Chen, BM; Hsieh, TJ; Dashnyam, P; Kuo, YH; Tu, Z; Roffler, SR; Lin, CH or send Email.. COA of Formula: C7H8O
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles