Nonappa; Ahonen, Kari; Lahtinen, Manu; Kolehmainen, Erkki published an article in 2011, the title of the article was Cyclic dipeptides: catalyst/promoter-free, rapid and environmentally benign cyclization of free amino acids.Quality Control of H-Idc-OH And the article contains the following content:
With growing public concern over global warming and the amount of greenhouse gases, it is important to reduce the amount of chems. and eliminate waste, to obtain better results in a simple, selective, safe, and environmentally benign fashion compared to conventional tedious chem. synthesis. Herein, the authors disclose an environmentally benign, rapid, catalyst/promoter/coupling reagent-free cyclization procedure of free amino acids to furnish exclusively cyclic dipeptides (2,5-diketopiperazines, DKPs) in excellent or even quant. yields, along with their solid state self-assembling properties. This process is extremely simple and highly efficient with little or no traditional synthetic skills and without any chromatog. purification Synthesis of structurally diverse DKPs has been achieved with a dramatic decrease in the reaction time, the amount/number of solvents used, a significant increase in the yield and nearly complete elimination of waste. As a result, this is an excellent example for the environmentally benign, clean and green chem. concept. The most exciting outcome of this investigation is an unusual case of chiral self-recognition encountered upon the cyclization of rac-pipecolic acid, which resulted in the formation of the meso-product exclusively. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Quality Control of H-Idc-OH
The Article related to cyclic dipeptide diketopiperazine preparation amino acid catalyst free cyclization, crystal structure diketopiperazine cyclic dipeptide, pipecolic acid cyclization chiral self recognition and other aspects.Quality Control of H-Idc-OH
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles