In 2020.0 RSC ADV published article about TOPOISOMERASE-I INHIBITION; ANTIPROLIFERATIVE ACTIVITY; ANTITUMOR-ACTIVITY; BENZIMIDAZOLES; CYTOTOXICITY; DOCKING in [Thi-Kim-Chi Huynh; Thi-Hong-An Nguyen; Thi-Cam-Thu Nguyen; Thi-Kim-Dung Hoang] Inst Chem Technol VAST, 01 Mac Dinh Chi Str,Dist 1, Ho Chi Minh City, Vietnam; [Thi-Kim-Chi Huynh; Thi-Kim-Dung Hoang] Grad Univ Sci & Technol VAST, 18 Hoang Quoc Viet Str, Hanoi, Vietnam; [Thi-Cam-Thu Nguyen] Ton Duc Thang Univ, 19 Nguyen Huu Tho Str,Dist 7, Ho Chi Minh City, Vietnam in 2020.0, Cited 36.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4
In order to explore and develop new anticancer agents, three series of 2-phenylbenzimidazoles, 15-46, were condensed under simple and mild conditions using sodium metabisulfite as an oxidation agent and another series, 47-55, were obtained via a reduction reaction using sodium borohydride. All the compounds synthesized were evaluated for their in vitro anticancer activities against three human cancer cell lines. The novel compound 38 was found to be the most potent multi cancer inhibitor against A549, MDA-MB-231, and PC3 cell lines (IC50 values 4.47, 4.68 and 5.50 mu g mL(-1), respectively). In addition, compound 40 exhibited the best IC50 value of 3.55 mu g mL(-1) against the MDA-MB-231 cell line. The results demonstrated that introducing a new substituent to compounds 37-55 could improve their antiproliferative activities.
About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Huynh, TKC; Nguyen, THA; Nguyen, TCT; Hoang, TKD or concate me.. Recommanded Product: 100-83-4
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles