An article Design, crystal structures and sustainable synthesis of family of antipyrine derivatives: Abolish to bacterial and parasitic infection WOS:000492858500061 published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ORGANOSILATRANES; CHEMISTRY; AGENTS in [Singh, Gurjaspreet; Satija, Pinky; Sahoo, Subash Chandra] Panjab Univ, Dept Chem, Chandigarh 160014, India; [Singh, Baljinder] Panjab Univ, Dept Biotechnol, Chandigarh 160014, India; [Sinha, Shweta; Sehgal, Rakesh] PGIMER, Dept Med Parasitol, Chandigarh 160012, India in 2020.0, Cited 25.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Safety of 3-Hydroxybenzaldehyde
This work explores the facile synthesis of a series of antipyrine acetylinic framework (3a-3h). The newly synthesized compounds are recognized by IR, NMR (H-1, C-13), X-ray diffraction. This collection played indispensable role in the development of biologically active agents. Our goal is to enable adoption of green chemistry within the pharmaceutical industry for the benefit of society, industry and the environment. This work articulates a new possible scaffold for drug discovery against protozoal pathogens (Entamoeba histolytica and Giardia lamblia) and bacterial strain (Staphylococcus aureus, Vibrio cholera, E. coli, Bacillus subtillus). The purpose of the present undertaking is to put low price anti parasitic drug using green technology. It is envisaged that the alliance of anti pyrine derivative and acetylene framework into a single scaffold boosts the effectiveness of anti bacterial as well as anti-parasitic treatment and may be vital for meeting future challenges in medicinal world. (C) 2019 Elsevier B.V. All rights reserved.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles