An article Well-defined N-heterocyclic carbene/ruthenium complexes for the alcohol amidation with amines: The dual role of cesium carbonate and improved activities applying an added ligand WOS:000500909200001 published article about DIRECT AMIDE SYNTHESIS; RUTHENIUM-CATALYZED OXIDATION; DEHYDROGENATIVE AMIDATION; EFFICIENT CATALYSTS; BOND FORMATION; CARBENE; SYSTEMS; ALDEHYDES; PEPTIDES; METHANOL in [Wang, Wan-Qiang] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, 296 Longzhong Rd, Xiangyang 441053, Peoples R China; [Wang, Wan-Qiang; Yuan, Ye; Miao, Yang; Wang, Hua-Jing; Wang, Zhi-Qin; Sang, Wei; Chen, Cheng; Verpoort, Francis] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China; [Miao, Yang; Wang, Zhi-Qin; Sang, Wei; Verpoort, Francis] Wuhan Univ Technol, Sch Mat Sci & Engn, 122 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China; [Yu, Bao-Yi] Beijing Univ Agr, Key Lab Urban Agr North China, Minist Agr, Beinong Rd 7, Beijing 102206, Peoples R China; [Wang, Hua-Jing] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China; [Verpoort, Francis] Natl Res Tomsk Polytech Univ, Lenin Ave 30, Tomsk 634050, Russia; [Verpoort, Francis] Univ Ghent, Global Campus,119 Songdomunhwa Ro, Incheon 21985, South Korea in 2020.0, Cited 73.0. Product Details of 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
Dehydrogenative amide bond formation from alcohols and amines has been regarded as an atom-economic and sustainable process. Among various catalytic systems, N-heterocyclic carbene (NHC)-based Ru catalytic systems have attracted growing interest due to the outstanding properties of NHCs as ligands. Herein, an NHC/Ru complex (1) was prepared and its structure was further confirmed with X-ray crystallography. In the presence of Cs2CO3, two NHC/Ru-based catalytic systems were disclosed to be active for this amide synthesis. System A, which did not contain any added ligand, required a catalyst loading of 1.00 mol%. Interestingly, improved catalytic performance was realized by the addition of an NHC precursor (L). Optimization of the amounts of L and other conditions gave rise to system B, a much more potent system with the Ru loading as low as 0.25 mol%. Moreover, an NHC-Ru-carbonate complex 6 was identified from the refluxing toluene of 1 and Cs2CO3, and further investigations revealed that 6 was an important intermediate for this catalytic reaction. Based on the above results, we claimed that the role of Cs2CO3 was to facilitate the formation of key intermediate 6. On the other hand, it provided the optimized basicity for the selective amide formation.
Product Details of 100-51-6. Welcome to talk about 100-51-6, If you have any questions, you can contact Wang, WQ; Yuan, Y; Miao, Y; Yu, BY; Wang, HJ; Wang, ZQ; Sang, W; Chen, C; Verpoort, F or send Email.
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
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