Ma, Rui-Jun;Sun, Jian-Ting;Liu, Chang-Hong;Chen, Ling;Si, Chang-Mei;Wei, Bang-Guo published 《Synthesis of 1-benzylisoindoline and 1-benzyl-tetrahydroisoquinoline through nucleophilic addition of organozinc reagents to N,O-acetals》. The research results were published in《Organic & Biomolecular Chemistry》 in 2020.Name: 6-Methoxyisoindolin-1-one The article conveys some information:
A new approach to access 1-benzylisoindolines I [n = 1, 2; R1 = Bn, 4-FC6H4CH2, 4-t-BuC6H4CH2, etc.; R2 = H, 5-Br, 6-Cl, etc.] and 1-benzyl-tetrahydroisoquinolines I [R2 = H, 6,7-di-OMe] was developed through nucleophilic addition of organozinc reagents to N,O-acetals. A number of substituted organozinc reagents were amenable for this transformation, and the desired products were obtained with excellent yields. Moreover, Sc(OTf)3 proved to be an effective catalyst for the formation of 1-benzylisoindolines I and 1-benzyl-tetrahydroisoquinolines II using such nucleophilic addition And 6-Methoxyisoindolin-1-one (cas: 132680-54-7) was used in the research process.
6-Methoxyisoindolin-1-one(cas:132680-54-7 Name: 6-Methoxyisoindolin-1-one) is a class III topoisomerase inhibitor that binds to the chk1 protein, which is an enzyme involved in DNA replication. 6-Methoxyisoindolin-1-one inhibits the interaction between the chk1 protein and DNA, preventing DNA replication.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles