Room-Temperature Palladium-Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals was written by Ou, Wei;Xiang, Xudong;Zou, Ru;Xu, Qing;Loh, Kian Ping;Su, Chenliang. And the article was included in Angewandte Chemie, International Edition in 2021.SDS of cas: 199590-00-6 This article mentions the following:
Site-specific incorporation of deuterium into drug mols. to study and improve their biol. properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon-oxygen bonds in alcs. and ketones with D2 balloon for practical synthesis of deuterated pharmaceuticals and chems. with benzyl-site (sp3 C-H) D-incorporation. The highlights of this deoxygenative deuteration strategy are mild conditions, broad scope, practicability and high chemoselectivity. To enable the direct use of D2O, electrocatalytic D2O-splitting is adapted to in situ supply D2 on demand. With this system, the precise incorporation of deuterium in the metabolic position (benzyl-site) of ibuprofen is demonstrated in a sustainable and practical way with D2O. In the experiment, the researchers used many compounds, for example, (1-Methyl-1H-indol-6-yl)methanol (cas: 199590-00-6SDS of cas: 199590-00-6).
(1-Methyl-1H-indol-6-yl)methanol (cas: 199590-00-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.SDS of cas: 199590-00-6
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles