Authors Maran, BAV; Josmeh, D; Tan, JK; Yong, YS; Shah, MD in MDPI published article about in [Venmathi Maran, Balu Alagar; Josmeh, Dawglas; Shah, Muhammad Dawood] Univ Malaysia Sabah, Borneo Marine Res Inst, Jalan UMS 88450, Kota Kinabalu, Sabah, Malaysia; [Tan, Jen Kit] Univ Kebangsaan Malaysia, Dept Biochem, Med Ctr, Kuala Lumpur 56000, Malaysia; [Yong, Yoong Soon] Xiamen Univ Malaysia, Lab Ctr, Jalan Sunsuria, Bandar Sunsuria 43900, Sepang, Malaysia in 2021.0, Cited 52.0. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5
Zeylanicobdella arugamensis (Hirudinea), a marine parasitic leech, not only resulted in the mortality of the host fish (Groupers) but also caused economic losses. The current study aimed to elucidate the antiparasitic efficacy of the aqueous extract of the Azadirachta indica leaves against Z. arugamensis and to profile the composition via LC-Q Exactive HF Orbitrap mass spectrometry. Different concentrations (25, 50 and 100 mg/mL) of A. indica extract were prepared and tested on the parasitic leeches. The total mortality of leeches was noticed with an exposure to the A. indica aqueous extract. The average times required for the aqueous extract at concentrations of 25, 50 and 100 mg/mL to kill the leeches were 42.65 +/- 9.20, 11.69 +/- 1.11 and 6.45 +/- 0.45 min, respectively, in a dose-dependent manner. The Orbitrap mass spectrometry analysis indicated the presence of five flavonoids (myricetin 3-O-galactoside, trifolin, isorhamnetin, quercetin and kaempferol), four aromatics (4-methoxy benzaldehyde, scopoletin, indole-3-acrylic acid and 2,4-quinolinediol), three phenolics (p-coumaric acid, ferulic acid and phloretin) and two terpenoids (pulegone and caryophyllene oxide). Thus, our study indicates that A. indica aqueous extract is a good source of metabolites with the potential to act as a biocontrol agent against the marine parasitic leech in aquaculture.
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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles