Application In Synthesis of Benzyl Alcohol. Recently I am researching about BETA-LACTAM ANTIBIOTICS; RESISTANCE, Saw an article supported by the University Grants Commission-Basic Science Research (UGC-BSR), New Delhi, India; UGC, New Delhi, IndiaUniversity Grants Commission, India; National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Sahu, A; Sahu, P; Agrawal, R. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
A series of hybrid antimicrobial compounds were prepared by carboxylic acid protection of 6-aminopenicillanic acid using benzyl alcohol and thionyl chloride succeeded by azide displacement using trifluoromethanesulfonyl azide in dichloromethane. The azide thus formed was reacted with substituted alkynes to furnish benzyl-protected penicillin-triazole conjugates. Benzyl deprotection of the conjugates resulted in furnishing PNTCs under water methanol mixture using Pd/C as a catalyst. The PNTCs (7a-j) formed were screened for in vitro antibacterial potency against pathogenic strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes and antifungal potency against Candida albicans, Aspergillus niger, and Aspergillus clavatus. Further antimicrobial evaluation revealed compounds 7c, 7d, 7e, 7g, and 7i to be the most compounds of the series with minimum inhibitory concentration value for antibacterial in the range 0.5-50 mu g/mL and for antifungal in the range 9-300 mu g/mL. Toxicological analysis documented for compounds 7c, 7d, 7e, 7g, and 7i revealed compound 7i to be the most promising member of the series with 1000 and 500 mg/kg LD50, and no-observed-adverse-effect level to facilitate future clinical studies of the same.
Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Sahu, A; Sahu, P; Agrawal, R or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles