Indole Building Blocks

120-72-9, 1H-Indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 6 Methyl indolyl-3-glyoxylate A solution of indole (2.0 g, 1.70 mmol) in Et2O (20 mL) was cooled to 0-5C under N2and oxalyl chloride (1.5 mL 1.70 mmol) was added dropwise at <5C. The resultant yellow slurry was stirred 30 min. in the ice bath and was then cooled to -65C and a 25% wt. solution of sodium methoxide (7.8 mL, 3.4 mmol) was slowly added at <-58C. The reaction was then allowed to warm to room temperature, water was added (10 mL), and the resultant mixture filtered. The solid was dried at room temperature to give 3.21 g (93%) of the titled compound. NMR. MS (FD) m/z= 203 (M+, 100%). Analytical calculated for C11H9NO3C, 65.02; H, 4.46; N, 6.89. Found C, 64.93; H, 4.25; N, 7.03. 120-72-9, 120-72-9 1H-Indole 798, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; EP825190; (1998); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

143612-79-7, 3-(4-Chlorobutyl)-1H-indole-5-carbonitrile is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 15 A solution of 10.8 g of 3-[4-(N,N-bis(2-chloroethyl)amino)butyl]-5-cyanoindole (“E”) [obtainable by reaction of 3-(4-chlorobutyl)-5-cyanoindole with N,N-bis(2-chloroethyl)amine] and one equivalent of p-methoxyaniline in 200 ml of acetonitrile is stirred for 12 hours at room temperature and worked up in a conventional manner, and 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole, m.p. 207 (dec.), is obtained., 143612-79-7

The synthetic route of 143612-79-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Patent Gesellschaft mit Beschrankter Haftung; US5418237; (1995); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10075-50-0,5-Bromoindole,as a common compound, the synthetic route is as follows.

General procedure: A round-bottomed flask containing (28mL, 370mmol) freshly distilled dimethylformamide (DMF) was cooled to 0C for about 30min and freshly distilled phosphorus oxychloride (8.41mL, 90mmol) was subsequently added with stirring to the DMF over a period of 30min. A solution of indole 19 (85.47mmol) in DMF (10mL, 130mmol) was added to the yellow solution over a period of 1h. The solution was stirred at room temperature till it become a yellow paste. At the end of the reaction, 30g of crushed ice was added to the paste with stirring to make a clear cherry-red aqueous solution. Sodium hydroxide solution (1N, 100mL) was added dropwise with stirring to this cherry-red solution. The resulting suspension was heated rapidly to 90C and allowed to cool at room temperature, after which it was refrigerated for overnight. The product was filtered, washed with water (2¡Á100mL) and air-dried to afford pure indole-3-carboxaldehydes 20 in 80-90% yields. Indole-3-carboxaldehyde, pale yellow solid; mp 194-196C (Lit. [37]196-197C).

10075-50-0, The synthetic route of 10075-50-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tantak, Mukund P.; Klingler, Linus; Arun; Kumar, Anil; Sadana, Rachna; Kumar, Dalip; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 184 – 194;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

198479-63-9, 5-(Benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,198479-63-9

General procedure: The indole (5) dissolved in THF (10 mL) was added dropwise toa stirring mixture of NaH in THF (10 mL) at 0 C under N2 atmosphere.The mixture was stirred for 10 min, at which point theappropriate dibromoalkane (6)-(10) was added and the mixturewas stirred for 30 min at 0 C. The reaction was refluxed for a further30 min under N2 atmosphere, the mixture was allowed to coolat which point water was added dropwise until the solutionbecame clear. The solvent was then evaporated under reducedpressure to obtain a brown oil. The resin was dissolved in DCM(50 mL) and washed with water (3 50 mL), brine (50 mL) anddried over Na2SO4. The solvent was evaporated under reducedpressure to obtain a brown oil. The material was purified via flashchromatography over silica gel to afford the desired product.

The synthetic route of 198479-63-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kelly, Patrick M.; Bright, Sandra A.; Fayne, Darren; Pollock, Jade K.; Zisterer, Daniela M.; Williams, D. Clive; Meegan, Mary J.; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4075 – 4099;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3468-17-5,(1H-Indol-6-yl)methanamine,as a common compound, the synthetic route is as follows.

General procedure: To solutions of 2-(2,4-dichlorophenoxy)propanoic acid (100 mg,0.43 mmol) in DMF (2 mL) were added 2-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyl uronium hexafluorophosphate (HATU; 200 mg,0.53 mmol), the corresponding benzylamines (0.50 mmol), anddiisopropylethylamine (100 lL, 0.57 mmol). The resulting mixtureswere stirred at room temperature for 16 h, then poured intowater (20 mL). The aqueous mixtures were then stirred at roomtemperature until solids precipitate. The solids were filtered,rinsed with water, and dried to provide solids that were recrystallizedfrom CH2Cl2/hexane to provide the products 34a-y.

3468-17-5, 3468-17-5 (1H-Indol-6-yl)methanamine 17221101, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Article; Williams, John D.; Torhan, Matthew C.; Neelagiri, Venugopal R.; Brown, Carson; Bowlin, Nicholas O.; Di, Ming; McCarthy, Courtney T.; Aiello, Daniel; Peet, Norton P.; Bowlin, Terry L.; Moir, Donald T.; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 1027 – 1043;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

2338-71-8, 5-Fluoro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 6-methyl-N1-(4-(pyrdin-3-yl)pyrimidin-2-yl) benzene-1,3-diamine (compound 6) (0.5 mmol) and 5-substituted, indoline-2,3-dione(isatins) or indole and aromatic aldehydes(0.5 mmol) were taken in methanol (5 ml) and stirred at60 C temperature for 4-8 h. The reaction was monitored by TLC using methanol and chloroform (2%) as a solventsystem. After completion of reaction this mixture wasevaporated by vacuum distillation and the residue wasextracted with ethyl acetate (25 mL ¡Á 3). The organic solutionwas dried over anhydrous Na2SO4 and evaporated thesolvent to offered crude product. This was further purifiedby column chromatography using 0.1:10 methanol/chloroformas eluent to obtain the pure compound in good yield., 2338-71-8

Big data shows that 2338-71-8 is playing an increasingly important role.

Reference£º
Article; Rahim, Abdul; Syed, Riyaz; Poornachandra; Malik, M. Shaheer; Reddy, Ch. Venkata Ramana; Alvala, Mallika; Boppana, Kiran; Sridhar; Amanchy, Ramars; Kamal, Ahmed; Medicinal Chemistry Research; vol. 28; 5; (2019); p. 633 – 645;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1092114-59-4,3-Iodo-1H-indole-5-carbonitrile,as a common compound, the synthetic route is as follows.

1092114-59-4, General procedure: To a 5 mL round bottom flask containing 0.1 g of 3-iodoindole was added 2.0 mL of DMSO followed by NIS (10 mol%) and IBX (3.0 equiv). The resultant reaction mixture was stirred at 30 ¡À 5 C. After completion of the reaction as monitored by TLC analysis, the product was isolated following the work-up procedure described above.

As the paragraph descriping shows that 1092114-59-4 is playing an increasingly important role.

Reference£º
Article; Chandra, Ajeet; Yadav, Navin R.; Moorthy, Jarugu Narasimha; Tetrahedron; vol. 75; 14; (2019); p. 2169 – 2174;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.83515-06-4,5-Bromo-2-phenyl-1H-indole,as a common compound, the synthetic route is as follows.

83515-06-4, A stream of nitrogen under 2-nitrophenylboronic acid (11.04 g, 66.14 mmol) and the preparation example 18 of In the obtained 5-bromo-2-phenyl-1H-indole (15 g, 55.12 mmol), NaOH (6.61 g, a mixture of 165.36 mmol) and THF / H2O (200 ml / 100 ml), and then insert the Pd (PPh3) 4 (3.18 g, 5 mol) in 40 , was stirred for 12 hours at 80 .After completion of the reaction, extracted with methylene chloride, and then filtered into a MgSO4. After removal of the solvent in the resulting organic layerColumn chromatography (Hexane: EA = 5: 1 (v / v)) to give 5- (2-nitrophenyl) -2-phenyl-1H-indole to obtain a (10.74 g, yield 62%). 1H-NMR: delta 6.88 (dd, 1H), 7.21 (d, 1H), 7.32 (m, 1H), 7.34 (d, 1H), 7.46 (m, 3H), [0382] 7.64 (m, 2H), 7.77(d, 2H), 8.02 (d, 2H), 11.73 (s, 1H).

83515-06-4 5-Bromo-2-phenyl-1H-indole 838923, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; Doosan Co. Ltd.; Lee, Young Hwan; Kim, Tae Hyoung; Son, Hyo? Seok; Bae, Hyeong Chan; Park, Ho Cheol; Lee, Chang Jun; Shin, Jin Young; Baek, Young Mi; (97 pag.)KR101571589; (2015); B1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

40047-23-2, 6-Hydroxyindole-2-carboxylic acid is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of A (500 mg, 1.61 mmol) and 221-1 (286 mg, 1.61 mmol) and K2CO3 (446 g, 3.23 mmol) in DMSO (4 mL) is heated for 2 h at 140 ¡ãC and 10 h at 150 ¡ãC. The reaction is poured into H2O, extracted thrice with EtOAc, washed thrice with saturated aqueous NaHCO3, dried over Na2SO4, filtered and concentrated to give 221-2. The aqueous phase is acidified with concentrated HCl and extracted four times with EtOAc, washed with H20, dried over Na2SO4, filtered and concentrated to provide additional 221-2.

40047-23-2, As the paragraph descriping shows that 40047-23-2 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ABEYWARDANE, Asitha; BRUNETTE, Steven Richard; BURKE, Michael Jason; KIRRANE, Thomas Martin, Jr.; MAN, Chuk Chui; MARSHALL, Daniel Richard; PADYANA, Anil Kumar; RAZAVI, Hossein; SIBLEY, Robert; SMITH KEENAN, Lana Louise; SNOW, Roger John; SORCEK, Ronald John; TAKAHASHI, Hidenori; TAYLOR, Steven John; TURNER, Michael Robert; YOUNG, Erick Richard Roush; ZHANG, Qiang; ZHANG, Yunlong; ZINDELL, Renee M.; WO2014/14874; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-72-4,5-Fluoro-2-methylindole,as a common compound, the synthetic route is as follows.

5-Fluoro-2-methylindole (0.45Kg, 3.017mol, l.Owt), powdered potassium carbonate (1.251Kg, 9.05mol, 2.78wt) and acetonitrile (9.0L, 20vol) were charged to a 2OL EPO flange flask at 15 to 250C. Ethyl bromoacetate (0.671L, 2.67mol, 1.49vol) was added and the resulting suspension heated to and maintained at reflux for 18h after which time in-process check analysis by 1H NMR1 indicated 87% conversion. A further charge of ethyl bromoacetate (0.333L, 1.32mol, 0.74vol) and powdered potassium carbonate (0.626Kg, 4.53mol, 1.39wt) was made and reflux conditions established for a further 6 hours. In-process check by 1H NMR1 analysis indicated 98.4% conversion. The flask contents were allowed to cool to 15 to 250C over 16 hours. The solids were removed by filtration and the filter-cake washed with acetonitrile (2x IL, 2x 2vol). The combined filtrates were concentrated to dryness under vacuum at up to 4O0C (water bath) to provide crude Stage 1 as a brown oil (1.286Kg). The crude product was purified by dry flash chromatography using a gradient elution from heptanes to heptanes:toluene to toluene to give ethyl-(5-fluoro- 2-methylindolyl-l-acetate) as an off-white solid (0.573Kg, 80.7% theoretical, corrected for residual toluene). Mixed fractions were re-chromatographed as appropriate., 399-72-4

399-72-4 5-Fluoro-2-methylindole 2778715, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; OXAGEN LIMITED; WO2006/92579; (2006); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles