2-alkylation of 3-alkyindoles with unactivated alkenes was written by Pan, Xuling;Liu, Qian;Nong, Yingling. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Quality Control of 5-Chloroindole-3-carboxaldehyde This article mentions the following:
An acid-catalyzed 2-alkylation of indole mols. is developed. Only catalytic amount of the com. available, inexpensive and traceless hydriodic acid is used as the sole reaction promoter. 2,3-Disubstituted indole mols. bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 5-Chloroindole-3-carboxaldehyde (cas: 827-01-0Quality Control of 5-Chloroindole-3-carboxaldehyde).
5-Chloroindole-3-carboxaldehyde (cas: 827-01-0) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 5-Chloroindole-3-carboxaldehyde
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles