Nitrosoarene-catalyzed regioselective aromatic C-H sulfinylation with thiols under aerobic conditions was written by Pradhan, Suman;Patel, Sandeep;Chatterjee, Indranil. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Related Products of 4769-96-4 This article mentions the following:
Aromatic amines, e.g. PhX (X = Me2N, Et2N, PhNH, morpholin-4-yl, etc.), and (hetero)arenes, such as indoles and pyrroles, were regioselectively sulfinylated using aryl thiols RSH (R = Ph, 4-MeC6H4, 4-ClC6H4, 2-thienyl, 2-pyridyl, etc.) under mild aerobic conditions using nitrosoarenes as a redox-catalyst to give (arylsulfinyl)amines p-XC6H4S(O)R, 3-(arylsulfinyl)indoles and 2-(arylsulfinyl)pyrroles. The nitrosoarene is involved in the electron transfer process with arenes to generate a crucial arene radical cation intermediate for C-H sulfinylation. The present methodol. requires no directing group, could be scaled up easily and is applicable for the late-stage functionalization of drug mols. and natural products with high regioselectivity. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Related Products of 4769-96-4).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Related Products of 4769-96-4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles