Krasowska, D; Iraci, N; Santi, C; Drabowicz, J; Cieslak, M; Kazmierczak-Baranska, J; Palomba, M; Krolewska-Golinska, K; Magiera, J; Sancineto, L in [Krasowska, Dorota; Drabowicz, Jozef; Sancineto, Luca] Polish Acad Sci, Ctr Mol & Macromol Studies, Div Organ Chem, Sienkiewicza 112, PL-90363 Lodz, Poland; [Iraci, Nunzio] Univ Salerno, Dept Pharm, Via G Paolo II 132, I-84084 Salerno, Italy; [Santi, Claudio; Palomba, Martina] Univ Perugia, Dept Pharmaceut Sci, Via Liceo 1, I-06123 Perugia, Italy; [Drabowicz, Jozef] Jan Dlugosz Univ Czestochowa, Inst Chem, Armii Krajowej 13-15, PL-42200 Czestochowa, Poland; [Cieslak, Marcin; Kazmierczak-Baranska, Julia; Krolewska-Golinska, Karolina; Magiera, Jakub] Polish Acad Sci, Ctr Mol & Macromol Studies, Div Bioorgan Chem, Sienkiewicza 112, PL-90363 Lodz, Poland published Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors in 2019.0, Cited 73.0. Recommanded Product: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.
A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.
Recommanded Product: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Krasowska, D; Iraci, N; Santi, C; Drabowicz, J; Cieslak, M; Kazmierczak-Baranska, J; Palomba, M; Krolewska-Golinska, K; Magiera, J; Sancineto, L or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles