Recently I am researching about DRUG-DELIVERY; PHARMACOKINETICS; PERMEATION; ENHANCERS; CAPRATE; MUCOSA; SPRAY, Saw an article supported by the . Recommanded Product: 100-51-6. Published in SPRINGER in NEW YORK ,Authors: Hsu, HJ; Yang, Y; Pavuluri, V; Abraham, C; Naraharisetti, SB; Ashraf, M; Al-Ghabeish, M. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
Naloxone is an opioid antagonist with high affinity for -opioid receptor, and for this reason it is used for the emergency treatment of opioid overdose. Originally, it was available only as an injectable product. However, for the ease of administration, intranasal (IN) formulations have also become available. These IN formulations contain preservatives and stabilizers such as benzalkonium chloride (BKC), benzyl alcohol (BA), and ethylenediaminetetraacetic acid (EDTA). Some of these ingredients are known to affect permeability of drugs. This study focuses on investigating the effect of formulation variables including choice of preservatives, stabilizer, and pH on the permeability and stability of naloxone IN formulations. The in vitro permeability of naloxone was evaluated employing EpiAirway tissue-mounted Ussing chambers. BKC was found to enhance the apparent permeability (P-app) of naloxone significantly (p<0.05) at very low concentration, while BA caused similar enhancement at a much higher concentration. EDTA was found to decrease P-app of naloxone by lowering the pH, and the P-app of naloxone was found to decrease approximately 51-fold with the decrease in formulation pH from 6.0 to 4.0. The product stability was, however, found optimal only below pH 5.0. Thus, selection of formulation ingredients, buffering agent, and pH of IN formulation is a balancing act for achieving desired permeability and optimal stability to achieve reasonable shelf life of naloxone IN formulation. About Benzyl Alcohol, If you have any questions, you can contact Hsu, HJ; Yang, Y; Pavuluri, V; Abraham, C; Naraharisetti, SB; Ashraf, M; Al-Ghabeish, M or concate me.. Recommanded Product: 100-51-6
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles