Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Safety of Indole-5-carbonitrile, Which mentioned a new discovery about 15861-24-2
Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C?H Alkylation by alpha-Diazotized Meldrum’s Acid
A practical and straightforward protocol for IrIII-catalyzed regioselective carbenoid insertion C?H alkylation mediated by alpha-diazotized Meldrum’s acid was developed. The assistance of external additives and oxidants was not needed, and the developed IrIIIcatalysis proceeds in a highly efficient manner (e.g., mild reaction conditions, short reaction times and excellent regioselectivity) and demonstrates good compatibility with several privileged substrates, such as valuable N-(2-pyrimidyl)indoles, phenylpyridines, and the marketed drug edaravone and its analogues, and thus provides a good complement to previous methods for the rapid construction of the corresponding alkylated products.
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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles