Synthesis and screening method of new isatin derivatives was written by Rajini Priya, V.;Aruna Devi, M.;Raghunandan, N.;Venkateshwar Rao, J.. And the article was included in Journal of Pharma Research in 2013.Recommanded Product: 7-Nitroindoline-2,3-dione This article mentions the following:
The compound isatin derivatives I (R = H, 7-CH3, 5-Cl, etc.) were prepared by the treatment of 2-chloro-N1-[2-oxo-1,2-dihydro-3H-indol-3-ylidene] acetohydrazides with 1H-benzimidazole-2-ylmethanethiol in good yields. All the compounds were screened for their anti-inflammatory activities. The compound I (R = 5-CH3, 7-CH3) exhibited maximum activity with percentage of inhibition of 68.56 and 61.41. All the synthesized compounds showed mild to moderate anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Recommanded Product: 7-Nitroindoline-2,3-dione).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Recommanded Product: 7-Nitroindoline-2,3-dione
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles