Synthesis and characterization of cytotoxic activity of certain n-(6-benzoyl-1H-benzo [d] imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2014.SDS of cas: 103030-10-0 This article mentions the following:
A series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides I [R = H, 5-CH3, 5-Cl, 5-Br, 5-NO2, 7-NO2, 7-CH3] were synthesized by treating (5-benzoyl-1H-benzo[d]imidazol-2-yl) carbamates II with different substituted isatins. All the synthesized derivatives I were screened for anticancer activity against Hela using MTT assay and produced a dose dependent inhibition of growth of the cells. The IC50 values of all the synthetic test compounds were found between 16.03 to 41.75. The potency of (IC50 values) of cytotoxicity of compounds was compared with that of known cytotoxic agent, Cisplatin. Among all the synthesized novel compound I (R = 5-Cl) showed the most potent activity against MCF-7 cell lines. In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0SDS of cas: 103030-10-0).
Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 103030-10-0
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles