Cytotoxic, antioxidant and anti-inflammatory activity of N-(6-benzoyl-1H-benzo [d]imidazol-2-yl)-2-(2-oxosubtituted indolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Harikiran, L.;Sammaiah, G.. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2016.HPLC of Formula: 112656-95-8 This article mentions the following:
In the present study novel series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxosubstitutedindolin-3-ylidene) hydrazine carboxamides (III a-m) have been synthesized in good yields and characterized by IR, NMR and mass spectral analyses. The compounds were evaluated for their preliminary in vitro cytotoxic activity against HCT-116 (colon ) and HepG2 (hepatocellular) cancer cell lines by standard MTT assay, antioxidant activity by standard DPPH assay method and also were screened for in vitro anti-inflammatory activity by TMPD assay method. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8HPLC of Formula: 112656-95-8).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 112656-95-8
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles