1008-07-7, 7-Chloro-1H-indole-3-carbaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of Chloro-1H-indole-3-carbaldehyde (100 mg, 0.56 mmol) in MeOH (10 mL) was treated with hydroxylammonium chloride (43 mg, 0.61 mmol), stirred at 23 C for 3 h and treated with nickel(ll) chloride hexahydrate (139 mg, 0.59 mmol). The mixture was cooled to – 78 C, treated portionwise with sodium borohydride (421 mg, 1 1.1 mmol), stirred at -78 C for 1 h before being warmed to RT slowly and stirred until gas evolution had ceased. The mixture was filtered through a syringe filter and evaporated. The residue was dissolved in aqueous 1 % NH3 (30 mL), extracted with EtOAc (3 x 20 mL), dried over anhydrous Na2S04, filtered and evaporated to give the crude ((7-chloro-1 indol-3-yl)methanamine (100 mg, 99%). The product was unstable and was used immediately in the next step without further purification., 1008-07-7
As the paragraph descriping shows that 1008-07-7 is playing an increasingly important role.
Reference：
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (138 pag.)WO2018/229197; (2018); A1;,
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