Al Mahmud, H; Seo, H; Kim, S; Islam, MI; Sultana, OF; Nam, KW; Lee, BE; Sadu, VS; Lee, KI; Song, HY in [Al Mahmud, Hafij; Seo, Hoonhee; Kim, Sukyung; Islam, Md Imtiazul; Sultana, Omme Fatema; Song, Ho-Yeon] Soonchunhyang Univ, Sch Med, Dept Microbiol & Immunol, Cheonan 31151, Chungnam, South Korea; [Nam, Kung-Woo] Soonchunhyang Univ, Dept Life Sci & Biotechnol, Asan 31538, Chungnam, South Korea; [Lee, Byung-Eui] Soonchunhyang Univ, Sch Life Sci, Dept Chem, Asan 31538, Chungnam, South Korea; [Sadu, Venkata S.; Lee, Kee-In] Univ Sci & Technol, Major Green Chem & Environm Biotechnol, Daejeon 34113, South Korea; [Lee, Kee-In] Korea Res Inst Chem Technol, Green Chem Div, Daejeon 34114, South Korea published Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis in 2021.0, Cited 41.0. Recommanded Product: 150-19-6. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.
Aim: Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. Materials & methods: We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Results: Initially, 2-nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among x15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 mu g/ml). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. Conclusion: These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis.
Recommanded Product: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Al Mahmud, H; Seo, H; Kim, S; Islam, MI; Sultana, OF; Nam, KW; Lee, BE; Sadu, VS; Lee, KI; Song, HY or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles