15903-94-3, 6-(Benzyloxy)-1H-indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: General procedure for I catalyzed cascade Michael addition-hemiketalization reaction and the subsequent BF3¡¤Et2O promoted Friedel-Crafts alkylation reaction To a stirred solution of catalyst I (15 mol percent) and 2-((E)-2-nitrovinyl)phenols (8, 1 mmol) in toluene (2.5 mL), acetone (5 equiv, 5 mmol) was added. The resulting solution was stirred at 25 ¡ãC. After the reaction was complete (monitored by TLC), the reaction mixture was concentrated under reduced pressure and the crude product was purified by column chromatography on silica gel (200-300 mesh, PE/EtOAc=10/1) to afford the desired lactol intermediates 9 or open-chain compound 12. To a mixture of the obtained lactols 9 and indoles (10, 1.2 equiv) in acetonitrile (1 mL), BF3¡¤OEt2 (60 mol percent) was added portionwise at 25 ¡ãC. The resulting mixture was stirred at the same temperature for 10 h. The reaction mixture was concentrated in vacuo and the crude products were purified by column chromatography on silica gel (200-300 mesh, PE/EtOAc=10/1) to afford the desired 2-indolylchromanes 11. The title compounds were fully characterized by 1H NMR, 13C NMR, HRMS and specific rotation data. The enantiomeric excess of the pure products was determined by HPLC analysis using a chiral stationary phase.
15903-94-3, As the paragraph descriping shows that 15903-94-3 is playing an increasingly important role.
Reference£º
Article; Pan, Jianping; Wang, Yuehua; Chen, Shanren; Zhang, Xueqin; Wang, Youming; Zhou, Zhenghong; Tetrahedron; vol. 72; 1; (2016); p. 240 – 246;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles