3770-50-1, Ethyl indole-2-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of ethyl 1H-indole-2-carboxylate (2 mmol) in dry DMF (10 mL) was added NBS (2 mmol). The resulting mixture was stirred at room temperature under nitrogen gas for 12 h. Crushed ice was added into the reaction mixture. White precipitate appeared was collected under vacuum suction, washed with cold water, dried, and re-crystallized from ethanol to get pure product (1) (0.49 g, 90%); mp146-148 C; FTIR (KBr, cm-1) numax: 3377, 3297, 1686,1573, 1515, 740, 642; 1H NMR (400 MHz, CDCl3): delta =9.28 (s, 1H, NH), 7.67 (m, 1H, Ar-H), 7.40 (m, 2H, Ar-H),7.25 (m, 1H, Ar-H), 4.49 (q, J = 7.12 Hz, 2H,COOCH2CH3), 1.47 (t, J = 7.08 Hz, 3H, COOCH2CH3); 13C NMR (100MHz, CDCl3): delta = 161.16 (C,COOCH2CH3), 135.41 (C, C-2), 128.01 (C, C-7a), 126.57(CH, C-4), 121.47 (CH, C-5), 121.33 (CH, C-6), 112.06 (CH, C-7), 98.31 (C-Br, C-3), 61.54 (CH2, COOCH2CH3),14.36 (CH3, COOCH2CH3); ESI-MS (m/z): [M+Na]+Calcd for C11H10BrNO2: 266.98; Found: 289.98., 3770-50-1
As the paragraph descriping shows that 3770-50-1 is playing an increasingly important role.
Reference£º
Article; Singh, Amanjot; Verma, Raman K.; Kuhad, Anurag; Mall, Rajiv; Medicinal Chemistry Research; vol. 26; 4; (2017); p. 745 – 759;,
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