I found the field of Chemistry very interesting. Saw the article Temperature Sensing of Thiolate Addition by Phenolate Merocyanine Dyes: Importance of the Quinone Methide Resonance Structure published in 2021. Safety of 4-Methoxybenzaldehyde, Reprint Addresses Manderville, RA (corresponding author), Univ Guelph, Dept Chem, Guelph, ON N1G 2W1, Canada.; Manderville, RA (corresponding author), Univ Guelph, Dept Toxicol, Guelph, ON N1G 2W1, Canada.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde
Merocyanine (MC) dyes containing an aromatic donor vinyl linked to a cationic acceptor serve as chemosensors for analyte detection. Their electrophilicity permits anion detection through addition reactions that disrupt dye conjugation. Herein, we demonstrate the temperature influence on thiolate addition to MCs containing the N-methylbenzothiazolium (Btz) acceptor. The zwitterionic phenolate dye (PhOBtz) displays impressive temperature sensitivity to thiolate addition, with the brightly colored phenolate favored upon heating and the colorless thiolate adduct favored upon cooling. In contrast, MC dyes containing neutral donors (PhOMeBtz and PhNMe(2)Btz) display only moderate temperature sensitivity to thiolate capture and release. Extraction of thermodynamic parameters demonstrates a strong enthalpic driving force for thiolate addition to PhOBtz that is absent for PhOMeBtz and PhNMe(2)Btz. Variable temperature H-1 NMR studies demonstrate that PhOBtz adopts the para-quinone methide (p-QM) resonance structure. Thus, thiolate addition to PhOBtz resembles 1,6-conjugate addition to p-QMs which is accompanied by a large increase in the pi-stabilization energy upon adduct formation. Manipulation of PhOBtz electrophilicity by attaching chlorine substituents to the phenolate caused the thiolate adducts to dissipate over time for p-QM regeneration. Our work provides new design ideas for the utility of phenolate MC dyes, given that they are carriers of the p-QM electrophile.
Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Van Riesen, AJ; Johnson, RE; Al-Abdul-Wahid, MS; Liota, C; Christyanton, A; Manderville, RA or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles