487-89-8,487-89-8, Indole-3-carboxaldehyde is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of indole 3-carboxaldehyde (8y) (100 mmol) in ethanol (500 mL) at RT was added potassium hydroxide (1.1 equiv). The mixture was stuffed until total solubilization. The ethanol was completely removed in vacuum and the residual was dissolved in acetone (250 mL) followed by adding benzenesulfonyl chloride (1.1 equiv, 110 mmol). The reaction mixture was stuffed forhalf hour. The precipitate was filtered off and the filtrate was concentrated and recrystallized from methanol to give a white solid. Yield: 33%. ?H NMR (500 MHz, CDC13) oe 10.17 (s, 1 H), 8.25-8.39 (m, 2 H), 7.97-8.09 (m, 3 H), 7.69 (t, J= 7.33 Hz, 1 H), 7.59 (t, J= 7.5 Hz, 2 H), 7.39 -7.54 (m, 2 H). MS (ESI) calcd for C,5H,,N035 285.1, found 286.0 [M + Hf?.
487-89-8 Indole-3-carboxaldehyde 10256, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; WANG, Jin; CHEN, Jianjun; MILLER, Duane D.; LI, Wei; WO2014/138279; (2014); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles